Peptides For Weight Loss

Welcome to Dr. David Nazarian’s esteemed weight loss clinic in the heart of Los Angeles. He has been effectively using peptides for weight loss and muscle gain for many years. We can help you decide what are the best peptide for weight loss. If you’ve been tirelessly searching for a medically supervised, effective weight loss solution, you’ve just found your answer

Peptides For Weight Loss - Weight Loss Clinic LA

Peptides For Weight Loss 

Peptides are medications used to treat various health conditions such as obesity, optimizing blood sugar levels, etc. Today, we will be discussing peptides that are commonly used for weight loss treatment. If you want to know more about peptides and which will better suit your body’s needs, we strongly encourage you to book a consultation with us at Weight Loss Clinic LA.

What are peptides, and how do they function in weight-loss pills?

Peptides for weight loss are short chains of amino acids that are smaller than proteins and play various roles in the body. In the context of weight loss pills, certain peptides function by influencing physiological processes that contribute to weight management. Here’s how they work:

  • Appetite Regulation: Some peptides can affect the nervous system and increase the release of gut hormones that promote a feeling of fullness, leading to reduced food intake.
  • Insulin Secretion: Other factors improve insulin secretion and function, which helps lower blood sugar levels and prevent the accumulation of fat.
  • Fat Metabolism: Certain peptides can increase the rate at which fat is burned during exercise, enhancing weight loss efforts.

Types of Peptides for weight loss

Semaglutide

This peptide acts as an agonist for glucagon-like peptide 1 (GLP-1), helping maintain blood hormone levels of glucagon. Clinical trials have shown a significant 15% weight loss in subjects, demonstrating its effectiveness. The recommended dosage ranges from 0.25 to 2.4 mg/day.

Tesamorelin

Known for managing HIV-associated lipodystrophy, tesamorelin reduces visceral adipose tissue (VAT), particularly in the abdominal region. The typical dosage is 2 mg/day.

AOD 9604

Derived from growth hormone (GH), this peptide promotes lipolysis (fat breakdown) and inhibits lipogenesis. It utilizes body fat reserves, leading to weight loss. The recommended dosage is 300 mcg/day.

CJC-1295

By stimulating the release of growth hormone (GH) and insulin-like growth factor 1, CJC-1295 promotes fat breakdown in target cells like adipocytes (fat cells). Stacking it with Ipamorelin can enhance synergistic benefits for weight loss. The typical dosage is 250-300 mcg/day.

5-Amino-1MQ

Also known as an anti-obesity drug, this peptide inhibits an enzyme in cells, speeding up fat metabolism. It helps reduce blood cholesterol levels, ensuring a healthy lipid profile below the obesity range. The recommended dosage is 50 mg/day. 


Best Peptides For Weight Loss 


How do peptides target weight loss, and what mechanisms do they act upon in the body?

GLP-1 Agonists (Semaglutide)

Mechanism: These peptides mimic the action of glucagon-like peptide 1 (GLP-1), a hormone that regulates blood sugar levels. GLP-1 agonists enhance insulin secretion, delay gastric emptying, and reduce appetite.

Effect: By promoting satiety and slowing down digestion, they lead to reduced food intake and subsequent weight loss.

Tesamorelin

Mechanism: Tesamorelin stimulates the release of growth hormone-releasing hormone (GHRH). This, in turn, increases growth hormone (GH) levels.

Effect: Elevated GH levels enhance fat metabolism, particularly targeting visceral adipose tissue (VAT). Reduced VAT contributes to weight loss.

AOD 9604

Mechanism: Derived from GH, AOD 9604 selectively targets fat cells. It promotes lipolysis (breakdown of fat) and inhibits lipogenesis (fat synthesis).

Effect: By utilizing stored body fat, AOD 9604 aids in weight reduction.

CJC-1295

Mechanism: CJC-1295 stimulates the release of both GH and insulin-like growth factor 1 (IGF-1). It acts on adipocytes (fat cells).

Effect: Increased GH and IGF-1 levels enhance fat breakdown, contributing to weight loss.

5-Amino-1MQ

Mechanism: This peptide inhibits an enzyme involved in fat metabolism.

Effect: By accelerating fat breakdown, it helps maintain a healthy lipid profile and supports weight management.


Which Is The Best Peptides For Weight Loss 

This all depends on you as an individual and what your medical conditions are. We can go over all your medical history and recommend which is best peptide for weight loss and your needs. At times a combination of peptides can be the most effective. 



How it works

Contact us at +1 424-283-4273 to schedule an in office consult or virtual consult

or Book Online to receive your prescription of Wegovy or other Semaglutide or Trizepatide for weight loss.

  • Virtual Consult with MD & Nutritionist $450
  • 3 Month Supply of the best compounded semaglutide injection  $750 ( Special Pricing) 
  • Follow Ups $250
  • Lose 10 – 20% of body fat safely and effectively
Dr. David Nazarian

What research or studies support the efficacy and safety of peptides for weight loss?

Semaglutide

Multiple studies conducted in 2021 stated that 2.4 milligrams of Wegovy once a week could help in weight loss among patients. According to those studies, Wegovy was more effective than the placebo [1].

A 2022 study compared the effectiveness of semaglutide and liraglutide with the addition of diet and exercise for weight loss. The study suggested that semaglutide resulted in greater weight loss at 68 weeks than liraglutide [2].

Liraglutide

Another GLP-1 receptor agonist, liraglutide (brand name Saxenda), specifically targets weight loss. It reduces appetite and helps maintain weight loss for at least a year. Liraglutide is administered via a once-daily injection and has been found to be effective.

Another study conducted in 2021 showed 277 subjects taking 3 mg liraglutide per day lost 9 pounds (4.1 kg) [3].

Tirzepatide

A study conducted with participants with obesity issues stated that treatment with tirzepatide had an average weight loss of 10%-20% of their body weight after 72 weeks [4].

Tesamorelin

Along with reducing visceral adipose tissue (VAT) in patients diagnosed with HIV-associated lipodystrophy, Tesamorelin also resulted in trunk fat, waist circumference and waist-to-hip ratio reduction [5].

AOD9604

A report shared the evidence from a 12-week trial that a low dose of AOD9604 helps in weight loss in overweight patients [6].

CJC-1295

An article published in Peptide Sciences stated that the effects of CJC-1295, a synthetic derivative of growth hormone-releasing hormone (GHRH), may increase fat metabolism and muscle growth.

5-Amino-1MQ

According to Genemedics, the administration of 5-amino-1MQ resulted in significant weight loss without any adverse side effects in U.S. veterans military service members.

Another study found that the peptide was able to prevent fat accumulation and shrink fat cells, reducing the appearance of fat tissue [7].

Are peptides safe?

Weight loss peptides are generally considered safe when used under the supervision of a healthcare professional with little side effects.

What are the side effects of fat-loss peptides?

The most common side effects associated with GLP-1 receptor agonists, a class of peptides, are gastrointestinal issues like nausea, constipation, and diarrhea. These effects are usually mild to moderate and often occur when dosages are increased

What are the side effects of fat-loss peptides

What is the best peptide to take?

The best peptide for weight loss can depend on individual health goals, medical history, and specific body responses. However, based on available research and user experiences, Semaglutide is often highlighted as a highly effective option. Semaglutide is an FDA-approved medication for weight loss.

Are there potential psychological effects or mood changes associated with the use of peptides for weight loss?

The use of peptides for weight loss, particularly those that act as GLP-1 receptor agonists, can have various effects on the body, including potential psychological effects or mood changes. Peptides that reduce appetite and promote fullness can lead to changes in eating patterns, which may affect mood due to fluctuations in blood sugar levels and nutrient intake. 

Some peptides can influence the nervous system and increase the release of gut hormones that can increase the feeling of fullness, potentially affecting mood regulation.

Peptides For Weight Loss

Weight Loss Clinic LA offers the best peptides for weight loss near me in Beverly Hills but can also come to your home or office throughout the Los Angeles area. We serve patients near Beverly Hills, Bel Air, West Hollywood, Santa Monica, West Los Angeles, Culver City, Hollywood, Venice, Marina del Rey, Malibu, Manhattan Beach, Redondo Beach, Downtown Los Angeles, Encino, Woodland Hills, Sherman Oaks, Calabasas, Burbank, Glendale, Hidden Hills, Agoura Hills, Northridge, North Hollywood, Topanga, Canoga Park, Reseda, Valley Glen, Chatsworth, West Hills, Winnetka, Universal City, Silverlake, Echo Park, and many more.

References:

  1. Singh G, Krauthamer M, Bjalme-Evans M. Wegovy (semaglutide): a new weight loss drug for chronic weight management. J Investig Med. 2022;70(1):5-13. doi:10.1136/jim-2021-001952
  2. Rubino DM, Greenway FL, Khalid U, et al. Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial. JAMA. 2022;327(2):138–150. doi:10.1001/jama.2021.23619
  3. Haase CL, Serratore Achenbach MG, Lucrezi G, Jeswani N, Maurer S, Egermann U. Use of Liraglutide 3.0 mg for Weight Management in a Real-World Setting in Switzerland. Obes Facts. 2021;14(5):568-576. doi:10.1159/000518325
  4. Jastreboff AM, Aronne LJ, Ahmad NN, et al. Tirzepatide Once Weekly for the Treatment of Obesity. The New England Journal of Medicine. 2022;387(3):205-216. doi:https://doi.org/10.1056/nejmoa2206038
  5. Dhillon S. Tesamorelin: a review of its use in the management of HIV-associated lipodystrophy. Drugs. 2011 May 28;71(8):1071-91. doi: 10.2165/11202240-000000000-00000. PMID: 21668043.
  6. News Medical. Obesity drug codenamed AOD9604 highly successful in trials. News-Medical. Published December 16, 2004. Accessed February 28, 2024. https://www.news-medical.net/news/2004/12/16/6878.aspx
  7. Neelakantan H, Wang HY, Vance V, Hommel JD, McHardy SF, Watowich SJ. Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase. J Med Chem. 2017;60(12):5015–5028.

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