If you’re searching for an answer about whether metformin helps in weight loss, the short answer is yes. The long answer is a little complex, though, as metformin is a drug for type 2 diabetes and not approved by the FDA for weight loss. However, some research papers suggest metformin does help in weight loss.

If you want to know how check this article out or consult us at Weight Loss Clinic LA. 

What is metformin, and how does it work?

Metformin is a medication that helps lower blood sugar levels in people with type 2 diabetes. It works by decreasing glucose production in the liver, increasing the insulin sensitivity of body tissues, and increasing GDF15 secretion, which reduces appetite and caloric intake. 

Metformin is taken by mouth and is generally well tolerated. However, it has a small risk of causing low blood sugar or lactic acidosis, a dangerous build-up of lactic acid in the blood.

Functions of metformin

• Reducing Glucose Absorption: Metformin decreases glucose absorption from the intestines, helping to control blood sugar levels.
• Lowering Liver Glucose Production: It reduces sugar production by the liver, which contributes to elevated blood sugar levels.
• Improving Insulin Sensitivity: Metformin enhances the body’s sensitivity to insulin, making it more effective in regulating blood sugar.

Benefits of metformin

• Cardiovascular Benefits: Metformin not only helps lower blood sugar but also provides cardiovascular advantages. It reduces the risk of death due to cardiovascular disease in people with diabetes.
• Weight Management: Some individuals experience weight loss while taking metformin. It can be effective in controlling body weight and reducing excess pounds.
• Prediabetes: For those with elevated blood sugar (prediabetes), metformin may delay the onset of full-blown diabetes or even prevent it.
• Gestational Diabetes: Pregnant women with gestational diabetes can benefit from metformin to manage blood sugar during pregnancy.
• Polycystic Ovary Syndrome (PCOS): Metformin has been prescribed off-label for women with PCOS. It helps regulate menstrual cycles, improve fertility, and control elevated blood sugar.
• Potential Anti-Aging Effects: Recent interest surrounds metformin’s potential to slow aging and extend life expectancy. While more research is needed, its impact on aging is intriguing

Popular metformin medicines

• Glucophage: A common brand name for metformin.
• Glumetza: Another brand used for metformin.
• Glucophage XR: Extended-release metformin.
• Fortamet: A brand of metformin with extended-release properties.
• Riomet: A liquid form of metformin.

How does metformin contribute to weight loss?

Appetite suppression: Metformin can affect the central nervous system, which helps reduce appetite. This causes a person to eat food less than they usually do, which leads to weight loss.

Reduced absorption of glucose: Metformin helps the body use insulin more effectively, and as a result, it causes low blood sugar levels. When blood sugar is stable, the body is less likely to store excess glucose as fat.

Increased calorie expenditure: Studies suggest that metformin may increase calorie usage for energy and improve metabolic control. This may cause weight loss [1].

Promotion of fat oxidation: Metformin may burn fatty acids, making it easier for the body to use stored fat for energy.

Changes in gut microbiota: Metformin might influence the composition of gut bacteria, and some research suggests that alterations in the gut microbiota may be linked to changes in body weight.