Semaglutide can support weight loss primarily by reducing appetite, increasing feelings of fullness and slowing gastric emptying. Ozempic contains semaglutide and is FDA approved for type 2 diabetes; Wegovy also contains semaglutide and is FDA approved for chronic weight management in eligible patients.
Semaglutide is a GLP-1 receptor agonist. GLP-1 is involved in appetite regulation, glucose-dependent insulin secretion and several digestive processes. By activating GLP-1 receptors, semaglutide can make it easier for some patients to eat less without feeling as hungry.
Semaglutide acts on areas of the brain involved in appetite and satiety. Many patients report less food noise, smaller portions and fewer cravings, although the degree of effect varies.
The medication can slow the rate at which food leaves the stomach, particularly earlier in treatment. This can contribute to fullness but may also cause nausea, reflux, constipation or bloating in some patients.
Semaglutide is not a direct fat-burning stimulant. Fat loss occurs when overall energy intake decreases enough to create a sustained calorie deficit. The medication can make that deficit easier to maintain by improving appetite control.
Results vary based on the medication, dose, duration of treatment, nutrition, physical activity, starting weight and individual biology. Clinical trials of semaglutide for obesity have shown meaningful average weight loss, but no specific result can be guaranteed for an individual patient.
Any significant weight loss can include loss of lean mass. Adequate protein intake and resistance training can help support muscle preservation during treatment when medically appropriate.
Appetite may increase after semaglutide is discontinued, and some patients regain weight. Long-term weight management usually requires an ongoing strategy that may include medication, nutrition, exercise, sleep and behavioral support.
Semaglutide is not appropriate for everyone. A clinician should review medical history, medications, contraindications, side effects and treatment goals before prescribing it.
Learn more about our Semaglutide Program and weight loss medication options.
