Can You Take Phentermine and Wegovy Together | Weight Loss Clinic

Can You Take Phentermine and Wegovy Together - Weight Loss Clinic LA
  • Dr. David Nazarian
  • January 20, 2024
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Can You Take Phentermine and Wegovy Together?

Let’s check whether you can take Phentermine and Wegovy together. These are two different kinds of medicines that some people use to help them lose weight. Phentermine is like a turbo boost for energy and helps you eat less.

On the other hand, Wegovy works more slowly to make you feel less hungry over time. They sound like a great team, right? But here’s the catch: mixing them might not be a good idea.

Doctors say that taking these two together could be risky. They could make you feel weird side effects, like your heart racing fast or tired. Plus, it might even lead to more severe health issues. So, if someone is considering using these for weight loss, it’s super important to talk to a doctor first. They can help figure out what’s safe and what’s not.

Remember, it’s all about taking care of your health in the best way possible! Let’s dive into this topic and see what’s up with Phentermine and Wegovy.

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Can You Take Phentermine And Wegovy Together?

It is possible to take Wegovy (semaglutide) and phentermine together for weight management, but it should only be done under the guidance of a healthcare professional in a certified weight loss clinic.

However, there is a moderate drug interaction between phentermine and Wegovy, and the risk of the interaction outweighs the benefit.

It is essential to check with a weight loss professional about specific health needs and whether these medications are appropriate for an individual’s weight loss plan.

Additionally, combining phentermine and semaglutide could initiate severe side effects such as heart palpitations or extreme fatigue and lead to dire conditions like hypoglycemia.

Does Semaglutide Work Better Than Phentermine?

Semaglutide and phentermine are effective for weight loss, but they work differently. Phentermine is designed for short-term use and primarily works by reducing appetite and increasing energy, while semaglutide, like Wegovy, is meant for long-term weight management and works by slowing down the movement of the intestinal tract, reducing hunger, and increasing satisfaction.

A 2021 study noted that those who injected semaglutide showed more reduction in body weight than those taking phentermine.

Additionally, semaglutide has shown sustained weight loss even after the discontinuation of the medicine, making it a more viable long-term solution than phentermine, whose effects may diminish over time, with weight regain being common once the medication is discontinued.

However, it’s essential to check with a healthcare provider to help you determine the most appropriate medication for your individual needs.

Which Is Safer, Semaglutide or Phentermine?

The safety profiles of semaglutide and phentermine differ, and each has its own set of considerations regarding safety.


  • Semaglutide is considered safe for long-term use in weight management. It’s also used to treat type 2 diabetes.
  • Common side effects of semiglutide include gastrointestinal issues like nausea, vomiting, diarrhea, abdominal pain, and constipation.
  • It may not be suitable for individuals with certain medical conditions, such as a personal or family history of medullary thyroid carcinoma, and it’s not recommended for pregnant or breastfeeding women.
  • Semaglutide has a risk of causing pancreatitis and changes in vision for diabetic retinopathy.
  • It’s important to monitor for any signs of serious side effects and discuss them with a healthcare provider.


  • Phentermine is typically prescribed for a short-term weight loss goal, often for a period of 12 weeks or less, due to its potential for side effects and the risk of dependency.
  • Common side effects of phentermine include sleeplessness, constipation, faster heart rate, and nervousness.
  • It’s not suitable for individuals with certain health conditions such as heart disease, high blood pressure, an overactive thyroid gland, or glaucoma.
  • Phentermine can be habit-forming, which is a significant safety consideration.
  • Like semaglutide, it should not be used during pregnancy or breastfeeding.

In summary, the safety of either medication depends largely on the individual’s health profile and the specific conditions for which they are being treated.

While semaglutide is generally considered safe for long-term use and has a broader application (including for diabetes management), phentermine is typically limited to short-term use due to its potential side effects and habit-forming nature.

What Should You Not Take With Phentermine?

What Should You Not Take With Phentermine - Weight Loss Clinic LA

When taking phentermine, there are several substances and medications you should avoid due to potentially dangerous interactions:

  • Monoamine Oxidase Inhibitors (MAOIs): Taking phentermine with MAOIs can lead to a hypertensive crisis, a severe and sudden increase in blood pressure. MAOIs should be stopped at least 14 days before starting phentermine. Common MAOIs include Isocarboxazid, Phenelzine, Tranylcypromine, Linezolid, Methylene blue, Procarbazine, Rasagiline, and Selegiline.
  • Tricyclic Antidepressants (TCAs): TCAs can potentiate the pressor response of phentermine and cause a dangerous increase in blood pressure. Common TCAs include Amitriptyline, Clomipramine, Imipramine, Lofepramine, and Nortriptyline.
  • Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin/Norepinephrine Reuptake Inhibitors (SNRIs): These can interact with phentermine to potentially cause serotonin syndrome, a serious condition characterized by symptoms like irritability, hallucinations, rapid heart rate, etc. Common SSRIs include Citalopram, Escitalopram, Fluoxetine, Paroxetine, and Sertraline. SNRIs include Desvenlafaxine, Duloxetine, Levomilnacipran, and Venlafaxine.
  • Phenothiazines (Antipsychotics): Using phenothiazines with phentermine can interfere with the weight loss medication’s appetite-suppressing effects and may worsen psychotic states.
  • Other Weight Loss Pills: Inform your doctor about any other weight loss medication or supplement you have taken in the last year, including prescription appetite suppressants and over-the-counter weight loss aids.
  • Other Stimulants: Phentermine should not be combined with other stimulant medications due to the increased risk of cardiovascular and CNS side effects.
  • Medicines that Cause Drowsiness: Combining phentermine with substances that cause drowsiness can increase the risk of adverse effects like high blood pressure.
  • Antihypertensives: Phentermine can raise blood pressure, which directly opposes the treatment goals of antihypertensives.
  • Phentermine-Food Interactions: Consuming chocolate while taking phentermine should be avoided due to its mild stimulant properties.
  • Alcohol and Caffeine: These should be limited or avoided as they can interact with phentermine to increase the likelihood of hypertension or seizures.
  • Illicit Drugs: Strong stimulants like cocaine and methamphetamine must be strictly avoided while taking phentermine.
  • Other Considerations: Be cautious if you have conditions like cardiovascular disease, hyperthyroidism, glaucoma, or renal impairment, as phentermine can exacerbate these conditions.

Final Words

So, we’ve explored the big question: Can you take Phentermine and Wegovy together?

It turns out it’s not a simple ‘yes’ or ‘no.’ While both meds can help with weight loss, using them together can be risky. They could cause some not-so-great side effects, leading to bigger health issues.

The key takeaway? Always chat with a doctor before mixing any medications, especially when it’s about managing your weight. They’ll help you find the safest and most effective plan.

Remember, staying healthy is about making smart choices, sometimes, that means asking for professional advice. Stay informed and take care of yourself!

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